导师简介—杨勇
【时间】:2020-09-25 【来源】:
导师姓名:杨勇
招生专业:临床检验诊断学
联系方式:yangyong@dlu.edu.cn
个人简介:杨勇,讲师,医学博士,药理学教研室教师,辽宁省百千万人才工程万层次人才,大连市药学会科技创新人才。近年主持国家自然科学基金项目1项,大连市科技创新基金项目1项,发表学术论文10余篇,其中被SCI收录6篇。获省自然科学学术成果奖1项,主要承担《药理学》、《中药药理学》、《实验动物学》等本科生课程及《中药药理学与实验设计》等研究生课程。
主要研究领域:药物性肝损伤作用机制研究
教育及研究工作经历
2007.8-2011.6 延边大学药学院 药学专业 医学学士
2011.9-2016.6 延边大学药学院 药物化学专业 医学博士(硕博连读)
2016.7-至今 大连大学 医学院 讲师
承担主要科研项目
国家自然科学基金项目:HMGB1介导NLRP3炎性小体活化诱导肝细胞焦亡在药物性肝损伤中的作用机制研究,2020.01-2022.12,21万元(主持)
大连市科技创新基金项目:大黄素甲醚调控AMPK信号通路干预药物性肝损伤的作用机制研究,2019.01-2020.12,10万元(主持)
大连大学博士启动基金项目:AMPK调控药物性肝损伤机制研究,2017.7-2019.6,1万元(主持)
国际合作项目:Development of functional Rhodiola sachalinensis complex extracts aimed at Chinese market,2016.04-2017.12,25.5万元(第二参与人)
发表论文
DONG Hui, YANG Li-hua, ZHAO Jie, ZHANG Jing, BAI Ting, YANG Yong*. Mechanism of NLRP3 inflammasome modulated hepatocyte pyroptosis in Drug-induced liver injury. Chin J Pharmacol Toxicol,2019,33(10):906-907.
Cui BW, Bai T , Yang Y, Zhang Y, Jiang M, Yang HX, Wu M, Liu J, Qiao CY, Zhan ZY, Wu YL, Kang DZ, Lian LH, Nan JX. Overdose-Induced Acute Liver Injury and Inflammation Via Regulation of JNK and AMPK Signaling Pathway. Am J Chin Med, 2019,47(3):577-594.
Yong YANG, Ting BAI, Ji-xing NAN, Qing-gao ZHANG. Hepatoprotective effect of thymoquinone against acetaminophen induced liver injury is associated with regulation of JNK and AMPK signaling pathway. Chin J Pharmacol Toxicol,2017,31(10):1007-1008.
Bai T, Yang Y(co-first author), Yao YL, Sun P, Lian LH, Wu YL, Nan JX*. Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway. Pharmacological research, 2016,105:1-12.
Yang Y1, Bai T1, Yao YL, Zhang DQ, Wu YL, Lian LH, Nan JX*. Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury. Toxicology letters, 2016, 262: 80-91.
Yong Yang†, Ting Bai†, Peng Sun, Li-Hua Lian, You-Li Yao, Hui-Xing Zheng, Xin Li, Jin-Bin Li, Yan-Ling Wu*, Ji-Xing Nan*. Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice. RSC Adv, 2015, 5:7285-7290.
Ting Bai,Yong Yang(co-first author), Yan-LingWu, Shuang Jiang, Jung Joon Lee, Li-Hua Lian*, Ji-Xing Nan*. Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice.Int Immunopharmacol, 2014, 15:351-357.
Bai T, Yang Y, Lian LH, Wu YL, Jiang S, Zheng HX, Li X, Li JB, Yao YL, Nan JX. The anti-fibrotic effect of thymoquinone on thioacetamide-induced mouse hepatic fibrosis. Acta Pharmacologica Sinica, 2013,34:21.
上一条:导师简介—陶雅军
下一条:导师简介--张庆镐
【关闭窗口】
|