导师简介----王茜茜

导师简介----王茜茜

导师姓名：王茜茜

招生专业：临床检验诊断学

联系方式：wangqianqian@dlu.edu.cn

个人简介

博士，讲师，硕士导师，辽宁省“百千万人才工程”万层次人才，大连市新引进高层次人才，大连市城市发展紧缺人才。近年主持和参与国家省市级科研项目4项，以第一作者或通讯作者发表SCI高水平学术论文16篇，专利4项。澳门特别行政区研究生科技研发奖获得者。主要承担《医学统计学》等本科生课程，《循证医学》等研究生课程。

研究方向：计算生物学，药物设计

主要研究领域：

1. 炎症相关慢性疾病发病机制及天然产物活性筛选研究

2. 药物与靶标相互作用的多尺度分子模拟研究

3. 疾病靶点的药物分子设计和生物学活性研究

4. 基于自由能计算的药物/靶标选择性机制

热烈欢迎对计算生物学具有浓厚兴趣的青年学子报考硕士研究生!

教育及研究工作经历

2019.12---至今 大连大学医学院 讲师

2016.09---2019.08 澳门科技大学中医药学院 博士

2012.09---2015.06 兰州大学药学院  硕士

2008.09---2012.06 兰州大学药学院 学士

承担主要科研项目: 近年主持辽宁省自然科学基金1项，辽宁省教育厅高等学校基本科研项目1项目，大连市科技创新基金项目1项，大连大学引进博士启动基金1项。

发表论文

1. Wang Y, Jin X, Fan Q, Li C, Zhang M, Wang Y, Wu Q, Li J, Liu X, Wang S, Wang Y, Li L, Ling J, Li C, Wang Q*, Liu Y*. Deciphering the Active Compounds and Mechanisms of HSBDF for Treating ALI via Integrating Chemical Bioinformatics Analysis. Front Pharmacol. 2022. 2;13:879268.

2. Wang Q, Zhang Q, Leung ELH, Chen Y, Yao X. Exploring the thermodynamic, kinetic and inhibitory mechanisms of 5-iTU targeting mitotic kinase haspin by integrated molecular dynamics. Phys Chem Chem Phys. 2021. 4;23(34):18404-18413.

3. Wang Q; Shao X; Leung ELH; Chen Y; Yao X. Selectively targeting individual bromodomain: Drug discovery and molecular mechanisms. Pharmacological Research, 2021, 172: 105804.

4. Chen Y; Jiang F; Kong G; Yuan S; Cao Y; Zhang Q; Wang Q*; Liu L*. Gasotransmitter CO Attenuates Bleomycin-Induced Fibroblast Senescence via Indu ction of Stress Granule Formation, Oxidative Medicine and Cellular Longevity, 2021, 2021: 9926284.

5. Chen Y, Shao X, Zhao X, Ji Y, Liu L, Li P, Zhang M, Wang Q*. Targeting protein arginine methyltransferase 5 in cancers: Roles, inhibitors and mechanisms. Biomed Pharmacother. 2021. 144:112252.

6. Xu, J.,^# Wang Q.,^# Leung E.,^# Li, Y., Fan, X., Wu, Q., Yao, X., Liu, L. Compound 620-0696, a new potent inhibitor targeting BPTF, the chromatin remodeling factor in non-small cell lung cancer. Front Med, 2020,14 (1):60-67.

7. Wang, Q., Xu, J., Li, Y., Huang, J., Jiang, Z., Wang, Y., Liu, L., Leung, E., Yao, X. Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening. Front Pharmacol, 2018, 9:173.

8. Wang, Q., Li, Y., Xu, J., Wang, Y., Shi, D., Liu, L., Leung E., Yao, X., Computational study on the selective inhibition mechanism of MS402 to the first and second bromodomains of BRD4. Proteins, 2019, 87(1):3-11

9. Wang, Q., An, X., Xu, J., Wang, Y., Liu, L., Leung, E., Yao, X. Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains. Org Biol Chem, 2018,16, 6521-6530.

10. Wang, Q., Li, Y., Xu, J., Wang, Y., Leung, E., Liu, L., Yao, X. Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations. Sci Rep, 2017, 7(1):8857.

11. Zhou, S.,^# Wang, Q.,^# Ren, M., Zhang, A., Liu, H., Yao, X. Molecular dynamics simulation on the inhibition mechanism of peptide-based inhibitor of islet amyloid polypeptide (IAPP) to islet amyloid polypeptide (IAPP22-28) oligomers. Chem Biol Drug Des, 2017, 90(1):31-39.

12. Wang, Q., Zhou, S., Wei, W., Yao, X., Liu, H., Hu, Z. Computational insights into the inhibition and destabilization of morin on the oligomer of full-length human islet amyloid polypeptide. Phys Chem Chem Phys, 2015, 17(43):29103-12.

13. Wang, Q., Ning, L., Niu, Y., Liu, H., Yao, X. Molecular mechanism of the inhibition and remodeling of human islet amyloid polypeptide (hIAPP(1-37)) oligomer by resveratrol from molecular dynamics simulation. J Phys Chem B, 2015, 119(1):15-24.

14. Wang, Q., Guo, J., Jiao, P., Liu, H., Yao, X. Exploring the influence of EGCG on the β-sheet-rich oligomers of human islet amyloid polypeptide (hIAPP1-37) and identifying its possible binding sites from molecular dynamics simulation. PLoS One, 2014, 9(4):e94796.

15. Wang, Q., Li, L., Wang, X., Liu, H., Yao, X. Understanding the recognition mechanisms of Zα domain of human editing enzyme ADAR1 (hZα(ADAR1)) and various Z-DNAs from molecular dynamics simulation. J Mol Model, 2014, 20(11):2500.

发明专利

1. Yao, X.^*, Leung, ELH.^*, Liu, L.^*, Wang, Q., Xu, J., Li, Y. Methods for Treating Cancer. United State Patent. Patent number: US 10,278,955 B1

2. Yao, X.^*, Leung, ELH.^*, Liu, L.^*, Wang, Q., Xu, J., Li, Y. Methods for Treating Cancer. Australia Patent. Patent number: 2018100078